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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: NPR1 All Species: 22.12
Human Site: S505 Identified Species: 44.24
UniProt: P16066 Number Species: 11
    Phosphosite Substitution
    Charge Score: -0.09
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P16066 NP_000897.3 1061 118919 S505 Q L E K E L A S E L W R V R W
Chimpanzee Pan troglodytes XP_001168194 1047 116964 S489 M L E K E L A S M L W R I R W
Rhesus Macaque Macaca mulatta XP_001085221 1047 116990 S489 M L E K E L A S M L W R I R W
Dog Lupus familis XP_547577 1060 118154 S504 Q L E K E L A S E L W R V R W
Cat Felis silvestris
Mouse Mus musculus P18293 1057 119091 S501 Q L E K E L V S E L W R V R W
Rat Rattus norvegicus P18910 1057 118933 S501 Q L E K E L V S E L W R V R W
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001517544 743 84256 K240 F A N T G H F K G N V V A I K
Chicken Gallus gallus
Frog Xenopus laevis NP_001083703 1056 120483 A499 R L E K E L A A E L W R I R W
Zebra Danio Brachydanio rerio NP_001038402 1067 121798 A511 K L E N E L T A Q L W R V H W
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q07553 1163 130896 T497 K H Y R Y E Q T L A G L L W K
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans Q09435 1137 128085 N530 R A E R A R I N A E W Q V P F
Sea Urchin Strong. purpuratus P16065 1125 126238 A538 Y R K R A Y E A A L D S L V W
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 61.2 61.2 91.6 N.A. 90.8 90.8 N.A. 48.5 N.A. 66.1 62.7 N.A. 31.5 N.A. 29.8 35.1
Protein Similarity: 100 73.8 73.8 95 N.A. 94.2 94.2 N.A. 58.6 N.A. 78.7 77.5 N.A. 47.8 N.A. 49 50.8
P-Site Identity: 100 80 80 100 N.A. 93.3 93.3 N.A. 0 N.A. 80 60 N.A. 0 N.A. 20 13.3
P-Site Similarity: 100 86.6 86.6 100 N.A. 93.3 93.3 N.A. 0 N.A. 100 80 N.A. 26.6 N.A. 53.3 40
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 17 0 0 17 0 42 25 17 9 0 0 9 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 0 0 0 0 0 0 0 9 0 0 0 0 % D
% Glu: 0 0 75 0 67 9 9 0 42 9 0 0 0 0 0 % E
% Phe: 9 0 0 0 0 0 9 0 0 0 0 0 0 0 9 % F
% Gly: 0 0 0 0 9 0 0 0 9 0 9 0 0 0 0 % G
% His: 0 9 0 0 0 9 0 0 0 0 0 0 0 9 0 % H
% Ile: 0 0 0 0 0 0 9 0 0 0 0 0 25 9 0 % I
% Lys: 17 0 9 59 0 0 0 9 0 0 0 0 0 0 17 % K
% Leu: 0 67 0 0 0 67 0 0 9 75 0 9 17 0 0 % L
% Met: 17 0 0 0 0 0 0 0 17 0 0 0 0 0 0 % M
% Asn: 0 0 9 9 0 0 0 9 0 9 0 0 0 0 0 % N
% Pro: 0 0 0 0 0 0 0 0 0 0 0 0 0 9 0 % P
% Gln: 34 0 0 0 0 0 9 0 9 0 0 9 0 0 0 % Q
% Arg: 17 9 0 25 0 9 0 0 0 0 0 67 0 59 0 % R
% Ser: 0 0 0 0 0 0 0 50 0 0 0 9 0 0 0 % S
% Thr: 0 0 0 9 0 0 9 9 0 0 0 0 0 0 0 % T
% Val: 0 0 0 0 0 0 17 0 0 0 9 9 50 9 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 75 0 0 9 75 % W
% Tyr: 9 0 9 0 9 9 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _